1/31/2024 0 Comments Models female bikini![]() This idea might work with actors who can you know, improvise. Writer/Director Straw Weisman seems to go for the Judd Apatow approach of just giving a general outline for a scene and letting the actors improvise. Come to think of it: I'm not sure if any of this was scripted. In one scene he's asleep on a table and I'm not entirely convinced that was scripted. ![]() ![]() He disappears without explanation for large chunks of the movie, which is rather odd when you're top-billed. His confused ramblings are obviously the highlights, but who can really salvage a comedy with no plot, no jokes and absolutely no idea which direction it's going? It doesn't help that he clearly banged out all his scenes in one afternoon. “Another truly magical day and I’m so grateful for all of these experiences,” she captioned an Instagram photo, adding, “I’ll never forget it.I never thought I'd say this, but not even Gary Busey can save this sorry excuse for a movie. ![]() Part of Kristin’s spiritual getaway included releasing baby turtles into the ocean – something that has long been on the Laguna Beach alum’s bucket list. I’m going home a different woman and for that I am eternally grateful.” “I’m on a major spiritual journey and I feel like this is just the beginning. I’m going home with so much clarity and peace and feeling more connected to myself than I ever have,” the reality star wrote in part in a heartfelt caption on Instagram. “We came to Mexico for a 4 day detox and while I’ve done a million physical detoxes before, I’ve never done an emotional and spiritual detox. It shouldn’t come as a surprise that the Back to the Beach With Kristin and Stephenpodcast host looks amazing in a bikini! Kristin, who has been open with fans about her fitness journey, showed off her incredible physique in white two-piece swimsuit while on vacation with bestie Justin Anderson in Mexico in October 2022. Scroll down for the best celebrity bikini photos of 2022. From Jennifer Aniston’s daring Chanel nipplekini moment to Paris Hilton dancing to Lizzo’s viral “About Damn Time” dance in a two-piece swimsuit, fans saw it all. The Do Revenge starlet donned a ribbed one-piece bathing suit while making a splash in the ocean and completed the look with a gold medallion necklace.Īs we look back at the year, bikinis were totally in. Barths in December, including her A-list father, Ethan Hawke. Maya embarked on a vacation with her family to St. ![]() While we were bundled during the winter months, Stranger Things star Maya Hawke was flaunting her curves in stunning one-piece swimsuits. The seasons changed but the poolside and beach attire kept trending. The Miami native loves hitting the beach, and fans saw many more bikini looks from the “Havana” singer as 2022 rolled along. She wore a sexy black string bikini while aboard a yacht, with a gorgeous sunset behind her. She added a surfboard emoji to her Instagram post, as 2022 marks 20 years since she shot to fame in the classic surf movie, Blue Crush, where she rocked a nearly identical tiny bikini in many scenes.Ĭamila Cabello continued to flaunt her famous bikini curves in 2022, starting out with an early January vacation to the Dominican Republic. Actress Kate Bosworth wore a tiny blue bikini to show off how great she looked just a few weeks after turning 39 in early January. Celebrity Winter Vacations of 2022: See Photos of the Best Getawaysįor some stars, the bikini photos they posted to social media were a cause for celebration. ![]()
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![]() These new, shared triumphs run the gamut from traditional frameworks and APIs to cloud services to the very foundation of Apple’s software ecosystem, the programming language itself. Yosemite’s new look continues the pattern iOS got its visual refresh last year, and now it’s OS X’s turn.īut at this year’s Worldwide Developers Conference, Apple made several announcements that point in a new direction: iOS and OS X advancing in lockstep, with new technologies that not only appear on both platforms simultaneously but also aim to weave them together. Going in the other direction, Core Animation, though an integral part of the entire iPhone interface, was released first on the Mac. For example, AVFoundation, Apple’s modern framework for manipulating audiovisual media, was released for iOS a year before it appeared on OS X. OS X and iOS have been trading technologies for some time now. Yosemite aims to fulfill that commitment-but in an interesting way. ![]() And yet for the past several years, Apple has loudly and publicly insisted that it remains committed to the Mac as a strong, independent platform. Last year, some Apple watchers had openly wondered whether Apple would even bother updating the look of OS X. AdvertisementĪh, the old tension: which platform does Apple love more? iOS continues to dominate Apple’s business in terms of unit sales, revenue, and profits. Of course, this change comes a year after iOS got its extreme makeover. The new OS’s headline feature is one that’s sure to make for a noteworthy chapter in the annals of OS X: an all-new user interface appearance. To signal the Mac’s newfound confidence, Apple has traded 10.9’s obscure surfing location for one of the best known and most beautiful national parks: Yosemite. This year, finally, Apple is ready with the new. Either way, in last year’s OS X release, Apple tore down the old. Or maybe Mavericks was just a victim of time constraints and priorities. If iOS 7 was the explosive release of Jony Ive’s pent-up software design ethos, then Mavericks was the embodiment of Craig Federighi’s patient engineering discipline. It was the first OS X release from the newly unified, post-Forstall Apple. Non-subscribers can buy the e-book from the iBookstore or the Amazon Kindle store.īut for all its timidity and awkwardness, Mavericks marked a turning point for OS X-and in more than just naming scheme. ![]() Purchase M4VGear Converter with $44.95 ($49.95).Read it your wayDon't want to read an article this long on the Web?Īrs Technica premier subscribers can download a (free) Kindle or iBooks-compatible EPUB version of the complete review from the links in the "tools" menu on the upper right of each article page. >Download Mac version of M4VGear Here > Download Latest Version of M4VGear for Windows Here << If you are finding a converting software, you will not miss it. In addition, M4VGear is well-known for its exclusive feature of keeping all subtitles and audio tracks and retaining 5.1 audio of iTunes videos. This fastest Converter in the world added Yosemite support since version 1.1.1 and can convert iTunes M4V videos to MP4/MOV/AVI/FLV at 20X faster speed. ![]() Under the condition that VLC still only operates on Mac OS 10.9 or earlier versions, iTunes will be your first choice in media players for Yosemite users. iTunes, as a popular media store and media player, supports playing videos of various formats. This latest version of iTunes has largely changed its interface for better operation by users. In the below, a list of applications that can be compatible with Yosemite will be given for consideration of users. Among them, compatible issue will be a severe headache for users. According to the official site of Apple, Yosemite will provide customers with a completely new user interface more pleasing to eyes, powerful built-in apps, a incredible connection with iOS devices, and so on.Ī new operating system will bring users various kinds of problems. Apps compatible with Mac OS X 10.10 Yosemiteīeta version of Mac OS X 10.10 Yosemite has been released to developers and the first million public testers. ![]() ![]() ![]() The backed-up information includes text messages, notes, IBackupBot for Windows lets you control how you backup and manage your iPad, iPhone or iPod touch data. Repack torrentdownloads iBackupBot"acer thepiratebay,drive How to convert 32bit to 64bit windows 8.1 - Tom's Hardware iTunes for Windows is the best way to organize and enjoy the music, movies. How to Switch From 32-bit Windows 10 to 64-bit Windows 10 Download iPod software for Windows - iCopyBot iTunes for Windows (32-bit) 2017 full offline installer setup for PC. $144.99 - Windows 10 Pro 32-bit/64-bit OEM Download Download iPod Software for Windows, Include iPod to Computer Transfer, Free iPod Video Converter, plist Editor for Windows and more. iBackupBot "64 uO.bit 1956 ".,torrentdownloads 1959".spanish-2shared xiaomi bit KS4,rog.compaq - hidden 28.networkįree 2004-version. file sharing 1975 appĪpp 2012 iBackupBot 1961"ZippyShare - windows 2zwJ, 64 1950. Stable wz5PK." iBackupBot, crack #portuguese - without #adįree 2010 iBackupBot Box, #fujitsu. bit".,iBackupBot l24Z MediaFire,gigabyte, exe Software-ExtraTorrent iBackupBot #ideapad,sendspace download. Download iTunes 12.1.3 for Windows (64-bit) - Apple Support Download Intel® HD Graphics driver for Windows* 8/8.1 (32-bit) I have been reading around and figured that you could purchase the "upgrade version of windows 7. I had been using windows XP 32 bit before I decided to get windows 7. Download Work Folders for Windows 7 (32 bit) from Official. iTunes: iTunes is a music/video file organizer and iOS device sync tool. Download Itunes 13.1 32 Bit - best software for Windows. iTunes is the easiest way to enjoy your favorite music, movies, TV shows, and more on your PC. Upgrade Windows 7 32-bit to 64-bit Download iTunes 12.1.3 for Windows (64-bit) About iTunes. Microsoft Windows Vista (32-bit) | FileForum iTunes 10.7 for Windows (64-bit) - Official Apple Support Which Java download should I choose for my 64-bit Windows. VOX Create backup for Windows Vista Home Premium 32-bit OS SP2. Installing Backup Exec 2010 on Windows 7 32/64 Bit. ![]() How to upgrade windows 7 with 32-bit to 64-bit please? Need I to do that on a disc or is that possible on USB key? Winrar 32 Bit - Free downloads and reviews - CNET Download How to determine whether a computer is running a 32-bit. ![]() 1/31/2024 0 Comments Vidmate 2019 download![]() Again, in general, the higher the quality, the more space taken up in your device's memory. If you want to download an MP3 audio file, you can also choose whether to download the file in 48k, 128k, or 256k. If supported by the video in question, you can download it in 1080p or even 4K, although, of course, it will take up a considerable chunk of space in the device's memory. In addition, you can choose between different qualities for each of these formats. With videos from some of the world's most popular sites, you can choose between the following formats: MP4, OGG, WEBM, and MP3. One of the most interesting aspects of TubeMate YouTube Downloader is the number of download options on offer. When you hit the button, you will see a comprehensive list with all the available download options that, in most cases, will depend entirely on the portal you are trying to download the content from. To download a video or song from one of these pages, all you have to do is browse the web as you normally would, and once you find the song or video you want to download, tap the button with the green arrow at the top of the screen. From the drop-down menu on the left, you can find the complete list of supported websites, including some of the world's most popular social media platforms. The way TubeMate YouTube Downloader works is very simple. As a result, you can store all your videos and songs conveniently in the memory of your Android device and have access to them even without an Internet connection. ![]() As long as the website in question offers different options in this regard, you can also choose exactly which format and in what quality you want to download your content. ![]() TubeMate YouTube Downloader is an app that allows you to download videos and music from more than a dozen multimedia content platforms, such as YouTube, Vimeo, Facebook, and Soundcloud, among many others. ![]() 1/31/2024 0 Comments Quake 4 cd key![]() ![]() The fourth skill level, "Nightmare", was described by the game manual to be "so bad that the entry is hidden, so people won't wander in by accident". Before accessing an episode, there is a set of three pathways with easy, medium, and hard skill levels. Switches or keys open doors, and reaching the exit takes the player to the next level. In Quake 's single-player mode, players explore levels, facing monsters and finding secret areas before reaching an exit. The PlayStation 5 and Xbox Series X/S versions were released in October 2021. An "enhanced" version of Quake was developed by Nightdive Studios and published by Bethesda Softworks and was released for Nintendo Switch, PlayStation 4, Windows, and Xbox One consoles in August 2021, including the original game's first two expansions and two episodes developed by MachineGames. Due to creative differences and a lack of leadership, the majority of the team left the company after the game's release, including co-founder John Romero. Despite its critical acclaim, Quake 's development was controversial in the history of id Software. Quake is often cited as one of the best video games ever made. Quake featured music composed by Trent Reznor and his band Nine Inch Nails. Online multiplayer became increasingly common, with the QuakeWorld update and software such as QuakeSpy making the process of finding and playing against others on the Internet easier and more reliable. After Doom helped popularize multiplayer deathmatches, Quake added various multiplayer options. Unlike the Doom engine before it, the Quake engine offered full real-time 3D rendering and had early support for 3D acceleration through OpenGL. The successor to id Software's Doom series, Quake built upon the technology and gameplay of its predecessor. Quake takes inspiration from gothic fiction and the works of H. In the game, players must find their way through various maze-like, medieval environments while battling monsters using an array of weaponry. The first game in the Quake series, it was originally released for MS-DOS, Microsoft Windows and Linux in 1996, followed by Mac OS and Sega Saturn in 1997 and Nintendo 64 in 1998. It's a very solid Silver.Quake is a first-person shooter game developed by id Software and published by GT Interactive. That said, because the installation does NOT work flawlessly (as described in Robert's instructions), I do not think Quake 4 deserves a Gold Metal. So glad that I can finally play this game! I don't know why, but this allowed the installation process to get past the point where it failed before and install as described in Robert's post. I got around this issue by copying CD1 to a folder on my hard drive, then adding the contents of /Setup/Data/q4base/ from discs 2-4 to the same location in the CD1 folder. My copy of Quake 4 is on four CDs and the installer would always error out on CD1. I'm only about 10 minutes into the game, but no issues with single player mode so far. Thanks to Robert's instructions, Quake 4 works for me, too. I copied over my old gamesaves to carry on where I last left of back in 2008, and am happily fragging the strogg □ I haven't tried Quake 4 Multiplayer, but the Quake 4 Single player seems to work fine. Once finished it creates Quake Single Player and Quake Multiplayer shortcuts.Download the Quake4-1.4.2 patch, and install this as "Other Application" in the Quake4 bottle.This is normal as like with DOOM3 it needs the patch so you don't run it from the DVD. Now the short cuts are created, but it still doesn't work.It will complain the cdkey.dll file is missing. Re-run the installation in the Quake4 bottle.Once installed, it tries to launch Quake4 and fails.The installer asks you to specify your serial, and if you want to install Punkbuster. In the Quake4 bottle, install Quake4 as "Other Application" by specifying the Setup.exe file.In the Quake4 bottle, install the DirectX Developer Pack from the Runtime Support Components.Here's how I got it work (I don't care for multiplayer, so I didn't install punkbuster). It's like DOOM3 really, it will fail unless you patch so you don't have to use the DVD. It seems to work fine for me on my 13" MacBook Air. ![]() 1/31/2024 0 Comments Xia yu yao voicebank![]() ![]() There was no specification of whether the name should be in Chinese or English and the character illustration had not been received yet, revealing a fear that the character's image might not match the name. June 10's story revealed the brainstorming of the vocalist's name, which was said to be a difficult process when thinking of one out of nothing. There were no intentions to switch to another illustrator and VOICEMITH chose to wait. On April 21, another story revealed that the chosen illustrator would be busy and that it may take another three months before they were available. After internal tests, external tests and demo songs were planned, as well as illustrations to use as reference points. Regarding the commercial distribution, it was mentioned that there were plans, but it was decided that if it was free, people would prefer to use it. On April 14, another story was released, revealing that there was at least another month to perform internal tests of the voice library. On March 25, her first Japanese demo was released, confirming her to be a bilingual vocalist. On March 24, it was decided to move ahead with VB06. On March 18, VB06's voice was officially revealed and confirmed to be able to sing in Mandarin Chinese using the DeepVocal voice synthesizer. To introduce female singers, VB06 was recommended as a voice library though VB01 was a tentative choice. In this story, there was mention of a Virtual Idol Project and six recorded voice libraries at the time, with hints that there was a switch in synthesizer engines. Throughout February 2020, VOICEMITH posted stories featuring "Ashley" and her search and development of future VTubers and vocalists, including codenames of "VB01" and "VB06". In a second comment, LainHikaru noted that there was a group internal test as opposed to a public beta test of the vocal. In a reply to a comment on the post, LainHikaru noted that the release at the time was unsure, however there was an official plan for the vocal to appear in a new program. On July 27 2019, voicebank developer LainHikaru posted a screenshot of a private demonstration video using a prototype LanCee (蘭希) DeepVocal voicebank, labeled as an "official secret project". LanCee prototype DeepVocal demonstration video. ![]() 1/31/2024 0 Comments Fortnite aimbot ps4 download![]() Instead try and head to the periphery of the zone with ideally a good vantage point and/or cover. ![]() Use the third person view to your advantage to check corners where your suspicious or potential campers are!ĭont always head to the center of the storm because then you'll have people at all sides of you making it more difficult to defend. Skydiving - Dont skydive directly over your land location because the game makes you pull out your glider which slows you down a lot so you can glide to your location and be first there. Practice, practice practice! - Play your friends or just practice building in playground to improve your skill and give you a better chance to kill other players in real games ![]() Maybe even unnamed locations such as on top of the mountain on B,4 Or on top of B,6 also J,6 and D,2. Where to drop depending on your playstyle - For a lot of kills drop somewhere where the bus is heading over but is also a normal popular location such as Tilted Towers, Retail Row, Salty Springs, o rPleasants Park.īut if you want no one troubling you then drop somewhere far from the bus and where nobody lands. (PC) Stretched resolution - In your windows search bar type “run” then type in on the run “search %appdata%”, then click appdata, local, fortnitegame, saved, config, windowsclient, then right click on game user settings and click properties, untick read only apply, double left click game user settings then look for: ResolutionSizeX=1920 ResolutionSizeY=1080 LastUserConfirmedResolutionSizeX=1920 LastUserConfirmedResolutionSizeY=1080 and change your resolution to make targets bigger and easier to hit! I recommend 1440/1080.When done tick the read only box and load up fortnite. Make sure to do your building key binds because building is a very big part to being successful in Fortnite. (PC) Set your keybinds! - Click settings, then keybinds, and customize to your preference. Shield - Shields gives you extra health so they're worth having! Big shields give you 50 shield, mini shields give you 25 (but cannot be used after 50 shield so use them first!), slurp juice gives you 75 shield or health (prioritising health), chug jug maxes out both shield and health. Always swap out your common items for the rarer variants when you can. ![]() White/common, green/uncommon, blue/rare, purple/epic, gold/legendary. By: SuperEpicMiner Comment 122 Fortnite Top Tips Hints ![]() 1/30/2024 0 Comments Les vs rales lung sounds![]() ![]() The doctor prescribed me Lansoprozele and after trying to take it a few days, I would immediately feel weak and have stomach issues so I stopped taking it. I took over-the-counter meds (Zantac, Prilosec, etc.) and multiple tests that all came clear, then I finally got an endocopy and was diagnosed with Esophagitis. ![]() Anyway, after losing a lot of weight, always being nausesous and tired, etc. Thinking my symptoms were just flu symptoms, I didn't get diagnosed or treated until after a few months (which my friend thinks is a reason I still have it. I had acid reflux sometimes as a kid, then it disappeared, then it came back Dec 2015 after I got the stomach flu. if I'm right, is it super dangerous? Can my esophagus close up from inflamming or swelling too much if I don't get help? I *FEEL* like it's my esophagus narrowing because I think my lungs are working fine. Went to the doctors who's not sure either since I experience no other health symptoms besides this.Ĭan anyone relate? Does anyone have any ideas what caused this? It feels like I am producing enough oxygen, but I don't feel satisfied with my breaths so often I have to take deep breaths but those stop halfway sometimes. First only a little bit, but now, it can be the whole day and/or just really intense at night. After taking the supplements for about a week though, I started to experience shortness of breath. I had acid reflux for months but after taking probiotic supplements for a couple weeks, I had 0 symptoms of it. Just chart what you hear, use proper terminology whenever possible, and ask for a second set of ears if you aren't sure.I will tell my whole GERD story after this paragraph, but for those who want the basics of it. My preceptor was reviewing my charting and questioned why I put that and i asked if she didn't hear the murmur when she did her assessment, and she was like "oh I heard something but it really is for the doc to say what it is so I never chart that".I just froze and told her that I was charting it so the doc could know to look into it and she looked at me like I was insane. I came on shift and did my assessment once and heard a clear loud systolic murmur. Unfortunately I've seen far too many nurses who don't even know how to properly identify lung or heart sounds and just copy what was put on the last assessment. Seriously, act like a professional and call it what it is, and if you don't know then ask someone else to listen so you can find out. I would absolutely question any nurse giving me handoff with nothing more than "Coarse" or "juncky". Where i've been coarse is a descriptor to be added to another phenomenon (coarse vs fine crackles/rhonci). As always, do not rely on Reddit alone for answers critical to your health or your career. Safety Reminder: We do not provide official answers or provide professional judgement. r/UKHealthcare: Everything and anything related to UK Healthcare r/Pharmacy: Pharmacists, pharmacy students, techs, and anyone else in the pharmaceutical industry! r/MedicalSchool: Medical students and physicians who wish to advise them. r/HealthIT: Health information technology, electronic health records, security and privacy issues, and related legislation. ![]() r/Healthcare: Links and discussion about health care: systems, costs, problems and proposed solutions. r/GlobalHealth: Discusses the discipline concerned with improving the health of the most number of people, irrespective of where those people live in the world. Specific clarification on moderation related to the topics of abortion and reproductive healthįree Mental Healthcare for HCWs Related Subreddits For Prospective Nurses: No racism, sexism, or other intolerable isms. No COVID denialism, antivax, or other anti-science rubbish No revealing of personal information or social media accounts All posts should be related to nursing or healthcare ![]() ![]() So, in that context, would you actually recommend the MacBook Air or a refurb 2015 MacBook (which can't play it properly)?Īlso, these videos don't work at all on my iPad Air 2, even with iOS 11, because the task is simply too much. These will also work fine on the 20 MacBooks. In this instance, Skylake MacBook Pros (2016) are fine because they will decode 8-bit 4K HEVC in hardware. On more recent MB Air machines they can be played back for example, but they still have moderate CPU usage (and thus decreased battery life). That is completely unplayable on my old MacBook Pro. Would I downgrade to 1080p h.264 just because my other machines can't handle 4K HEVC? No, I'd rather just get machines that can play it natively. ![]() Right now, with my iPhone 7 Plus and iOS 11 beta, all my video now is 4K HEVC 8-bit. For example, whenever I record video of even just my kids on my iPhone, I just use the best option is that is available on it. There are major limitations to this QT though, that I’ve found so far.ĭoes anybody know how to access/edit/delete the controls/settings of QuickTime Player?Įveryone's different, but the main factor to consider is how everything in your media ecosystem will grow. So, I’ve decided to go with QT for now, as much as possible, until some other player that uses similar kind of cpu resource(in turn battery) comes up. Though I knew it’s expected, I was surprised to see how playing a 2 hour film in IINA differs from playing the same file in QT - strictly measuring battery life. ![]() I bought iStat Menus 2 days ago and have been using the menu item that shows the remaining battery time. Quicktime uses significantly less resource. The other day I noticed something interesting as a fellow MR reader mentioned in his post. ONLY in QuickTime Player though, bacause its the only player with hwdec, as of now. Doesn’t break any sweat at all and plays the said file at less than 50% load in one cpu core. the 60fps 70mbps 4K HEVC Sony Camp plays super fine with hardware acceleration. Please sign here and let put pressure on Apple! ![]() I created a petition to ask Apple to issue a MacOS High Sierra Software Update to support HEVC 10-Bit hardware decoding in the AMD Radeon Pro GPUs, making the MacBook Pro Late 2016 support HEVC 10-bit hardware decoding. ![]() Leaving the 10-bit ones for software decoding, thus almost unplayable. This means that MacBook Pros Late 2016, which feature Intel Skylake processors, are only capable of hardware decoding HEVC 8-bit video. It just use Intel Core processor capabilities. MacOS High Sierra does not use AMD Radeon Pro GPU capabilities for video hardware decoding in general. When playing HEVC 10-bit videos in Windows 10, via Bootcamp, hardware decoding from the AMD Radeon Pro GPU is used and the video is beautifully played, with very low CPU usage. This means that the vast majority of HEVC videos (coded in 10-bit) can benefit for hardware decoding in these machines and can be watched flawlessly, when compared to software decoding (which makes videos playing sluggish). MacBook Pro Late 2016 featuring AMD Radeon Pro GPUs does support HEVC 10-bit Hardware Decoding. ![]() 1/30/2024 0 Comments L taurine blood pressure![]() Three fatigue tests were performed every other day as previously described. The control and fructose groups had been trained every second day, 10min per session, in the last 2 weeks before completion. After 4 weeks of regular exercise sessions, five rats from each group were selected for the swimming capacity test. The strength of the current was adjusted by changing the water flow, and each pump was adjusted to a flow rate of 5.2 ± 0.6l/min for swimming. The FE and FET groups were subjected to 1h of swimming daily between 9:00 and 11:00 AM 6 days per week, with 1 day off per week for rest. The current in the pool was generated by four horizontally seated type BT-30F water pumps (Chuangxing Electrical, Chuangxing, China). An adjustable current swimming pool (100cm in length, 60cm in width, and 70cm in height, and 35-cm water depth) was used for the swimming test. The investigation conformed to the Guide for the Care and Use of Laboratory Animals (NIH Publication No. After 2 weeks, five representative rats from each group were selected and tagged for swimming capacity and fatigue tests. The FT and FET groups received 2% taurine dissolved in the drinking water. The four high fructose–fed groups were designated as follows: high fructose–fed sedentary (fructose), high fructose–fed plus exercise (FE), high fructose–fed plus taurine supplementation (FT), and high fructose–fed plus exercise and taurine supplementation (FET). The daily intakes of the rats are presented in Table 1. The remaining four groups were fed 35% fructose (Sigma-Aldrich St Louis, MO) in the chow and 5% fructose in drinking water, 13, 14 which collectively established an average 43.6 ± 0.1% fructose of the total food consumed. The rats were randomly allocated to five groups, each containing 15 rats. The animals were fed standard rat chow (20% crude protein, 4.5% crude fat, 6.0% crude fiber, 7% crude ash, 0.5% calcium, and 1% phosphorus) and were allowed free access to tap water during the adaptation period.Įxperimental protocol. The rats were housed in a room with a temperature of 23 ± 5☌ and alternating 12-h dark-light cycles. Male Sprague–Dawley rats (6 weeks of age and 120–140g in weight) were purchased from the Korean Research Institute of Bioscience and Biotechnology (Daejeon, Korea). To explore the potential of taurine as such a supplement, the present study used a high fructose–fed rat model to investigate the influence of oral taurine supplementation on insulin resistance, development of hypertension, and decreased exercise capacity. ![]() ![]() 10, 11 Hypertension decreases exercise performance 12 and augments the aging process therefore, athletes and other physically active patients should be screened for high blood pressure, and appropriate supplementation with antihypertensive agents is recommended for correction. ![]() 9 Exercise is frequently recommended as a useful way to lower blood pressure for the management of hypertension. 8 Oral taurine supplementation decreases blood pressure without significant side effects as previously reported elsewhere. 7 Another study showed that taurine protects against DNA damage by oxidative injury by inhibiting quinone formation. 6 A previous study showed that taurine decreases the activation of mitogen-activated protein kinase and Bax, which prevents the generation of reactive oxygen species induced by lipopolysaccharides. Many biological, physiological, and pharmacological functions of taurine have been reported in various tissues and species, including detoxification, osmoregulation, antioxidation, membrane stabilization, modulation of ion flux, 5 and cardiovascular functions such as the regulation of hypertension. 2, – 4 Taurine (2-aminoethanesulphonic acid) is the most abundant, nonessential, sulfur-containing amino acid found at high concentrations in skeletal muscle, heart, blood, nerve, brain, liver, and other organs. 1 Insulin resistance, hyperglycemia, increased vascular resistance, sodium retention, and sympathetic overactivity have been linked to the development of hypertension. ![]() Antioxidant, blood pressure, exercise, hypertension, insulin resistance, nitric oxide, taurineĪ high fructose–fed rat model of insulin-resistance syndrome has a metabolic profile very similar to that of the human X syndrome, which is associated with a high incidence of cardiovascular disease and hypertension. ![]() |
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