1/30/2024 0 Comments L taurine blood pressure![]() Three fatigue tests were performed every other day as previously described. The control and fructose groups had been trained every second day, 10min per session, in the last 2 weeks before completion. After 4 weeks of regular exercise sessions, five rats from each group were selected for the swimming capacity test. The strength of the current was adjusted by changing the water flow, and each pump was adjusted to a flow rate of 5.2 ± 0.6l/min for swimming. The FE and FET groups were subjected to 1h of swimming daily between 9:00 and 11:00 AM 6 days per week, with 1 day off per week for rest. The current in the pool was generated by four horizontally seated type BT-30F water pumps (Chuangxing Electrical, Chuangxing, China). An adjustable current swimming pool (100cm in length, 60cm in width, and 70cm in height, and 35-cm water depth) was used for the swimming test. The investigation conformed to the Guide for the Care and Use of Laboratory Animals (NIH Publication No. After 2 weeks, five representative rats from each group were selected and tagged for swimming capacity and fatigue tests. The FT and FET groups received 2% taurine dissolved in the drinking water. The four high fructose–fed groups were designated as follows: high fructose–fed sedentary (fructose), high fructose–fed plus exercise (FE), high fructose–fed plus taurine supplementation (FT), and high fructose–fed plus exercise and taurine supplementation (FET). The daily intakes of the rats are presented in Table 1. The remaining four groups were fed 35% fructose (Sigma-Aldrich St Louis, MO) in the chow and 5% fructose in drinking water, 13, 14 which collectively established an average 43.6 ± 0.1% fructose of the total food consumed. The rats were randomly allocated to five groups, each containing 15 rats. The animals were fed standard rat chow (20% crude protein, 4.5% crude fat, 6.0% crude fiber, 7% crude ash, 0.5% calcium, and 1% phosphorus) and were allowed free access to tap water during the adaptation period.Įxperimental protocol. The rats were housed in a room with a temperature of 23 ± 5☌ and alternating 12-h dark-light cycles. Male Sprague–Dawley rats (6 weeks of age and 120–140g in weight) were purchased from the Korean Research Institute of Bioscience and Biotechnology (Daejeon, Korea). To explore the potential of taurine as such a supplement, the present study used a high fructose–fed rat model to investigate the influence of oral taurine supplementation on insulin resistance, development of hypertension, and decreased exercise capacity. ![]() ![]() 10, 11 Hypertension decreases exercise performance 12 and augments the aging process therefore, athletes and other physically active patients should be screened for high blood pressure, and appropriate supplementation with antihypertensive agents is recommended for correction. ![]() 9 Exercise is frequently recommended as a useful way to lower blood pressure for the management of hypertension. 8 Oral taurine supplementation decreases blood pressure without significant side effects as previously reported elsewhere. 7 Another study showed that taurine protects against DNA damage by oxidative injury by inhibiting quinone formation. 6 A previous study showed that taurine decreases the activation of mitogen-activated protein kinase and Bax, which prevents the generation of reactive oxygen species induced by lipopolysaccharides. Many biological, physiological, and pharmacological functions of taurine have been reported in various tissues and species, including detoxification, osmoregulation, antioxidation, membrane stabilization, modulation of ion flux, 5 and cardiovascular functions such as the regulation of hypertension. 2, – 4 Taurine (2-aminoethanesulphonic acid) is the most abundant, nonessential, sulfur-containing amino acid found at high concentrations in skeletal muscle, heart, blood, nerve, brain, liver, and other organs. 1 Insulin resistance, hyperglycemia, increased vascular resistance, sodium retention, and sympathetic overactivity have been linked to the development of hypertension. ![]() Antioxidant, blood pressure, exercise, hypertension, insulin resistance, nitric oxide, taurineĪ high fructose–fed rat model of insulin-resistance syndrome has a metabolic profile very similar to that of the human X syndrome, which is associated with a high incidence of cardiovascular disease and hypertension. ![]()
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